Four new lanostane triterpenoids featuring extended π-conjugated systems from the stems of Kadsura coccinea.
Qi-Qi ZhangKun HuHan-Dong SunPema-Tenzin PunoPublished in: Natural products and bioprospecting (2023)
Four new 14(13 → 12)-abeolanostane triterpenoids featuring extended π-conjugated systems, kadcoccitanes E-H (1-4), were obtained from the stems of Kadsura coccinea through using a HPLC - UV-guided approach. Their structural and configurational determination was accomplished through extensive spectroscopic analysis coupled with quantum chemical calculations. Kadcoccitanes E-H were tested for their cytotoxic activities against five human tumor cell lines (HL-60, A-549, SMMC-7721, MDA-MB-231, SW-480) but none of them exhibited activities at the concentration 40 μM.
Keyphrases
- molecular dynamics
- solid phase extraction
- photodynamic therapy
- endothelial cells
- ms ms
- density functional theory
- molecular docking
- simultaneous determination
- molecular dynamics simulations
- mass spectrometry
- high performance liquid chromatography
- pluripotent stem cells
- tandem mass spectrometry
- quantum dots
- cell proliferation
- high resolution
- anti inflammatory