Long non-coding RNA HOTAIR drives EZH2-dependent myofibroblast activation in systemic sclerosis through miRNA 34a-dependent activation of NOTCH.

Christopher W WassonGiuseppina AbignanoHeidi HermesMaya MalaabRebecca L RossSergio A JimenezHoward Y ChangCarol A Feghali-BostwickFrancesco Del Galdo

Published in: Annals of the rheumatic diseases (2020)

Our data indicate that the EZH2-dependent epigenetic phenotype of myofibroblasts is driven by HOTAIR and is linked to miRNA-34a repression-dependent activation of NOTCH signalling.

Keyphrases

long non coding rna
systemic sclerosis
poor prognosis
interstitial lung disease
cell proliferation
gene expression
dna methylation
rheumatoid arthritis
deep learning
signaling pathway