Expression profiles of TRPV1, TRPV4, TLR4 and ERK1/2 in the dorsal root ganglionic neurons of a cancer-induced neuropathy rat model.
Ahmad MaqboulBakheet E M ElsadekPublished in: PeerJ (2018)
The decreased expression of TRPV1 and TRPV4 is associated with high activation. The increased expression of TLR4 and ERK1/2 reveals earlier immune response and tumor progression, respectively, and their ultimate decrease is an indicator of nerve damage. We studied the possible role of TRPV1 and TRPV4 in transducing cancer-induced hyperalgesia. The possible treatment strategies of cancer-induced thermal and/or mechanical hyperalgesia using capsazepine, HC-067047 and ruthenium red are examined.
Keyphrases
- neuropathic pain
- papillary thyroid
- immune response
- spinal cord
- poor prognosis
- high glucose
- diabetic rats
- toll like receptor
- squamous cell
- spinal cord injury
- signaling pathway
- inflammatory response
- cell proliferation
- drug induced
- lymph node metastasis
- oxidative stress
- endothelial cells
- pi k akt
- dendritic cells
- squamous cell carcinoma
- young adults
- nuclear factor
- childhood cancer