Differential effects of four intramuscular sedatives on cardiorespiratory stability in juvenile guinea pigs (Cavia porcellus).

Ryan P SixtusCholawat PacharinsakClint L GrayMary J BerryRebecca Maree Dyson

Published in: PloS one (2021)

Ketamine and alfaxalone are the most effective sedatives for inducing short duration, stable sedation with minimal cardiorespiratory depression in guinea pigs, while diazepam is less-so. However, alfaxalone is the most appropriate sedative for longitudinal studies requiring multiple physiological timepoints.

Keyphrases

body composition
high intensity
depressive symptoms
pain management
case control
cross sectional
mechanical ventilation
intensive care unit
physical activity