Immune Profiling of Vulvar Squamous Cell Cancer Discovers a Macrophage-rich Subtype Associated with Poor Prognosis.
Mateja CondicAndrea RohrSoheila RiemannChristian StaerkTiyasha H AyubAnna DoeserThomas ZillingerSabine Merkelbach-BruseReinhard ButtnerWinfried BarchetChristian RudlowskiAlexander MusteaKirsten KüblerPublished in: Cancer research communications (2024)
Immunoprofiling in VSCC reveals subtypes with distinct clinical and biological behavior. Of these, the macrophage-rich VSCC subtype is characterized by poor clinical outcome and increased VEGF-A expression, providing a biomarker for risk stratification and therapeutic sensitivity.