Nicotinamide N-methyltransferase enhances chemoresistance in breast cancer through SIRT1 protein stabilization.

Yanzhong WangJin ZengWeiping WuShuduo XieHaitao YuGuoli LiTao ZhuFengying LiJie LuGavin Y WangXinyou XieJun Zhang

Published in: Breast cancer research : BCR (2019)

The results of this study demonstrate a novel correlation between the NNMT expression level and patient survival, suggesting that NNMT has the potential to become a new prognostic biomarker to predict the treatment outcomes of the clinical chemotherapy in breast cancer. Moreover, targeting NNMT or downstream SIRT1 may represent a new therapeutic approach to improve the efficacy of breast cancer chemotherapy.

Keyphrases

oxidative stress
locally advanced
poor prognosis
case report
binding protein
squamous cell carcinoma
radiation therapy
rectal cancer
long non coding rna
protein protein
amino acid