Droplet-assisted electrospray phase separation using an integrated silicon microfluidic platform.
Yan ZhangSungho KimWeihua ShiYaoyao ZhaoInsu ParkChristopher Kenji BrendenHrishikesh IyerPrasoon JhaRashid BashirJonathan V SweedlerYurii A VlasovPublished in: Lab on a chip (2021)
We report a silicon microfluidic platform that enables monolithic integration of transparent micron-scale microfluidic channels, an on-chip segmentation of analyte flows into picoliter-volume droplets, and a nano-electrospray ionization emitter that enables spatial and temporal separation of oil and aqueous phases during electro-spray for subsequent mass spectrometry analysis.
Keyphrases
- high throughput
- liquid chromatography
- mass spectrometry
- single cell
- circulating tumor cells
- tandem mass spectrometry
- deep learning
- ionic liquid
- high performance liquid chromatography
- convolutional neural network
- high resolution
- simultaneous determination
- gas chromatography
- capillary electrophoresis
- machine learning
- fatty acid