Impact of lifestyle Intervention on branched-chain amino acid catabolism and insulin sensitivity in adolescents with obesity.

Catherine Jachthuber TrubMetin BalikciogluMichael FreemarkJames BainMichael MuehlbauerOlga IlkayevaPhillip J WhiteSarah ArmstrongTruls ØstbyeSteven GrambowPinar Gumus Balikcioglu

Published in: Endocrinology, diabetes & metabolism (2021)

Weight reduction in adolescents is associated with increases in BCAA catabolism and improvements in insulin sensitivity. Our study underscores the therapeutic potential of manipulating BCAA catabolism to treat obesity-associated insulin resistance in adolescents and prevent progression to T2D.

Keyphrases

physical activity
weight loss
young adults
metabolic syndrome
insulin resistance
weight gain
type diabetes
amino acid
randomized controlled trial
body mass index
adipose tissue
body weight