COL10A1 expression distinguishes a subset of cancer-associated fibroblasts present in the stroma of high-risk basal cell carcinoma.

Mauro EspositoLaura YerlyPrachi ShuklaVictoria HermesFederica SellaZsolt BalazsEvelyn LattmannAizhan TastanovaPatrick TurkoRamon LangIsabel KolmRamon StaegerFrançois KuonenMichael KrauthammerJuerg HafnerMitchell P LevesqueGaetana Restivo

Published in: The British journal of dermatology (2024)

We identified COL10A1 as a marker of high-risk BCC, in particular of the sclerosing/infiltrative and basosquamous subtypes. We demonstrated at the single cell level that COL10A1 is expressed by a specific CAF population associated with the stroma of invasive BCC. This opens up new tailored treatment options as well as a new prognostic biomarker for BCC progression.

Keyphrases

basal cell carcinoma
single cell
poor prognosis
rna seq
high throughput
smoking cessation
long non coding rna