Endothelial, pericyte and tumor cell expression in glioblastoma identifies fibroblast activation protein (FAP) as an excellent target for immunotherapy.

Lisa M EbertWenbo YuTessa GargettJohn ToubiaParis M KollisMelinda N TeaBrenton W EbertCedric BardyMark van den HurkClaudine S BonderJim ManavisKathleen S EnsbeyMariana Oksdath MansillaKaitlin G ScheerSally L PerrinRebecca J OrmsbySantosh PoonnooseBarbara KoszycaStuart M PitsonBryan W DayGuillermo A GomezMichael P Brown

Published in: Clinical & translational immunology (2020)

Fibroblast activation protein is expressed by multiple cell types within glioblastoma, highlighting it as an ideal immunotherapy antigen to target destruction of both tumor cells and their supporting vascular network.

Keyphrases

single cell
cell therapy
binding protein
poor prognosis
protein protein
gene expression
small molecule