Efficacy and safety of aerosolized intra-tracheal dornase alfa administration in patients with SARS-CoV-2-induced acute respiratory distress syndrome (ARDS): a structured summary of a study protocol for a randomised controlled trial.

Jean-Philippe DésillesC GregoireC Le CossecJ LambertO MophaweM R LosserF LambiotteS Le TaconM CantierN EngrandP TrouillerJ Pottecher

Published in: Trials (2020)

The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1). In the interest in expediting dissemination of this material, the familiar formatting has been eliminated. This Letter serves as a summary of the key elements of the full protocol.

Keyphrases

acute respiratory distress syndrome
sars cov
extracorporeal membrane oxygenation
mechanical ventilation
randomized controlled trial
high glucose
diabetic rats
respiratory syndrome coronavirus
drug induced
replacement therapy
endothelial cells
oxidative stress
stress induced