SIRPα Mediates IGF1 Receptor in Cardiomyopathy Induced by Chronic Kidney Disease.

Sandhya S ThomasJiao WuGiovanni E DavogusttoMichael W HollidayKristin Eckel-MahanDaniela VerzolaGiacomo GaribottoZhaoyong HuWilliam E MitchHeinrich Taegtmeyer

Published in: Circulation research (2022)

Myokine SIRPα expression impairs insulin/IGF1R functions in cardiac muscle, affecting cardiometabolic signaling pathways. Circulating SIRPα constitutes an important readout of insulin resistance in CKD-induced cardiomyopathy.

Keyphrases

chronic kidney disease
binding protein
pi k akt
end stage renal disease
heart failure
signaling pathway
type diabetes
poor prognosis
high glucose
skeletal muscle
diabetic rats
growth hormone
drug induced
oxidative stress
adipose tissue
peritoneal dialysis
insulin resistance
induced apoptosis
weight loss