Immunotherapy in advanced non-small-cell lung cancer (NSCLC) after progression on chemotherapy: real-world results from a prospective institutional cohort.
Ullas BatraKundan Singh ChufalShrinidhi NathanyIrfan AhmadRahul Lal ChowdharyMansi SharmaPraveen JainMunish GairolaPublished in: Immunotherapy (2022)
Objective: To analyze the outcomes of patients receiving immunotherapy (IO) with advanced non-driver mutated non-small-cell lung cancer (NSCLC) after progression on systemic treatment. Methods: The overall survival (OS), progression-free survival (PFS) and best response to IO of 64 patients who met our inclusion criteria were analyzed. Results: Median follow-up, OS and PFS were 35.9, 7.1 and 3.2 months, respectively. On uni- and multi-variable analysis, better ECOG PS and fewer extra-thoracic metastases were associated with prolonged OS and PFS. Response to IO was associated with prolonged OS, while thoracic radiotherapy and isolated CNS involvement were associated with prolonged PFS. ECOG PS, thoracic radiotherapy and PDL1 status significantly influenced the likelihood of response to IO. Overall, 30% patients experienced any grade toxicity. Conclusion: Our results are concordant with reported trial outcomes and support the application of IO in Indian patients.
Keyphrases
- advanced non small cell lung cancer
- end stage renal disease
- free survival
- small cell lung cancer
- early stage
- ejection fraction
- chronic kidney disease
- spinal cord
- prognostic factors
- locally advanced
- peritoneal dialysis
- radiation therapy
- randomized controlled trial
- study protocol
- skeletal muscle
- glycemic control
- smoking cessation
- placebo controlled