Conformational changes in myeloperoxidase induced by ubiquitin and NETs containing free ISG15 from systemic lupus erythematosus patients promote a pro-inflammatory cytokine response in CD4+ T cells.
Daniel Alberto Carrillo-VázquezEduardo Jardón-ValadezJiram Torres-RuizGuillermo Juárez-VegaJosé Luis Maravillas-MonteroDavid Eduardo Meza-SánchezMaría Lilia Domínguez-LópezJorge Carlos Alcocer VarelaDiana Gómez-MartínPublished in: Journal of translational medicine (2020)
The ubiquitylated MPO has a differential effect on the induction of reactivation of CD4+ lymphocytes in patients with SLE, which may be related to structural changes by ubiquitylation at the catalytic site of MPO. Besides a lower ubiquitylation pattern, NETs of patients with SLE are characterized by the expression of ISG15, and the induction of IFNγ by Th1 cells.
Keyphrases
- systemic lupus erythematosus
- disease activity
- end stage renal disease
- chronic kidney disease
- ejection fraction
- newly diagnosed
- induced apoptosis
- poor prognosis
- peritoneal dialysis
- prognostic factors
- immune response
- dendritic cells
- small molecule
- cell cycle arrest
- rheumatoid arthritis
- peripheral blood
- cell death
- drug induced
- nk cells