PIK3CA Amplification Associates with Aggressive Phenotype but Not Markers of AKT-MTOR Signaling in Endometrial Carcinoma.
Frederik HolstHenrica M J WernerSiv MjøsErling A HoivikKanthida KusonmanoElisabeth WikAnna BergEven BirkelandWilliam J GibsonMari K HalleJone TrovikAndrew D CherniackKarl-Henning KallandGordon B MillsChristian F SingerCamilla KrakstadRameen BeroukhimHelga B SalvesenPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)
PIK3CA amplification is a strong prognostic marker and a potential marker for the aggressive SCNA-high subgroup of UCEC. Although PIK3CA amplification associates with some surrogate measures of increased PI3K activity, markers for AKT1-3 and MTOR signaling are decreased, suggesting that this signaling is not a predominant pathway to promote cancer growth of aggressive serous-like UCEC. Moreover, these associations may reflect features of the SCNA-high subgroup of UCEC rather than effects of PIK3CA amplification itself.