Bone Morphogenetic Protein-2 and Osteopontin Gene Expression in Epicardial Adipose Tissue from Patients with Coronary Artery Disease Is Associated with the Presence of Calcified Atherosclerotic Plaques.
María Luna-LunaSergio Criales-VeraDiana Jhoseline Medina-LeyteMariana Díaz-ZamudioAdriana Flores-ZapataDavid Cruz-RoblesMauricio López-MenesesSergio Olvera-CruzSamuel Ramírez-MarroquínCristóbal Flores-CastilloJosé Manuel FragosoElizabeth Carreón-TorresJesús Vargas-BarrónGilberto Vargas-AlarconÓscar Pérez-MéndezPublished in: Diabetes, metabolic syndrome and obesity : targets and therapy (2020)
EAT correlated with BMI and expressed the mRNA of calcifying genes but only OPN and BMP-2 expression was higher in CAD patients. Higher levels of both OPN and BMP-2 statistically determined the presence of calcium in coronary arteries of CAD patients.
Keyphrases
- end stage renal disease
- gene expression
- adipose tissue
- coronary artery disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- mesenchymal stem cells
- prognostic factors
- body mass index
- peritoneal dialysis
- type diabetes
- dna methylation
- coronary artery
- heart failure
- poor prognosis
- insulin resistance
- bone marrow
- physical activity
- high fat diet
- patient reported outcomes
- binding protein
- aortic valve