A balancing act: PHLPP2 fine tunes AKT activity and MYC stability in prostate cancer.

Roxanne ToivanenLuc Furic

Published in: The Journal of cell biology (2019)

PTEN loss stimulates prostate tumor progression by sustaining AKT activation. Nowak et al. (2019. J. Cell Biol https://doi.org/10.1083/jcb.201902048) surprisingly show that the AKT-suppressing phosphatase PHLPP2 promotes disease progression in the context of dual PTEN and p53 loss by increasing MYC stability.

Keyphrases

cell proliferation
prostate cancer
signaling pathway
pi k akt
radical prostatectomy
transcription factor
single cell
poor prognosis
air pollution
stem cells
mesenchymal stem cells
long non coding rna