Knockdown of G Protein-coupled Estrogen Receptor 1 (GPER1) Enhances Tumor-supportive Properties in Cervical Carcinoma Cells.

Sophia RuckrieglJohanna LorisKatsiaryna WertGerd BauerschmitzJulia GallwasCarsten Gründker

Published in: Cancer genomics & proteomics (2023)

GPER1 appears to be tumor suppressive in CC, as GPER1 knockdown provoked increased stem cell properties and increased migration/invasion. EMT also appears to be enhanced. Of interest is the increase in SERPINE1/PAI-1 expression after GPER1 knockdown.

Keyphrases

estrogen receptor
stem cells
poor prognosis
epithelial mesenchymal transition
binding protein
cell migration
signaling pathway
cell therapy
bone marrow