Oxidized LDL regulates efferocytosis through the CD36-PKM2-mtROS pathway.

Jue ZhangJackie ChangVaya ChenMirza Ahmar BegWenxin HuangLance VickYaxin WangHeng ZhangErin YttreAnkan GuptaMark CastleberryZiyu ZhangWen DaiShan SongJieqing ZhuMoua YangAshley Kaye BrownZhen XuYan-Qing MaBrian C SmithJacek ZielonkaJames G TraylorCyrine Ben DhaouA Wayne OrrWeiguo CuiZe ZhengYiliang Chen

Published in: bioRxiv : the preprint server for biology (2024)

Macrophages clear apoptotic cells through a process called efferocytosis, which involves mitochondrial ROS. However, the atherogenic oxidized LDL overstimulates mitochondrial ROS via the CD36-PKM2 pathway, disrupting continual efferocytosis. This finding elucidates a novel molecular mechanism that explains defects in efferocytosis, driving atherosclerosis progression.

Keyphrases

low density lipoprotein
cell death
cell cycle arrest
oxidative stress
induced apoptosis
dna damage
reactive oxygen species
cardiovascular disease
endoplasmic reticulum stress
signaling pathway
pi k akt