Depleting inositol pyrophosphate 5-InsP7 protected the heart against ischemia-reperfusion injury by elevating plasma adiponectin.

Lin FuJimin DuDavid FurkertMegan L ShiptonXiaoqi LiuTim AguirreAlfred C ChinAndrew M RileyBarry V L PotterDorothea FiedlerXu ZhangYi ZhuChenglai Fu

Published in: Cardiovascular research (2024)

Our findings revealed that 5-InsP7 is a physiological regulator of adiponectin biosynthesis that is amenable to pharmacological intervention for cardioprotection.

Keyphrases

metabolic syndrome
insulin resistance
randomized controlled trial
heart failure
single cell
transcription factor
type diabetes
skeletal muscle