Ghrelin-insulin-like growth factor-1 axis is activated via autonomic neural circuits in the non-alcoholic fatty liver disease.
Takuro NagoyaKenya KamimuraRyosuke InoueMasayoshi KoTakashi OwakiYusuke NiwaNorihiro SakaiToru SetsuAkira SakamakiTakeshi YokooHiroteru KamimuraYuka NakamuraMasaki UenoShuji TeraiPublished in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2020)
Our study demonstrated that the fatty liver stimulates the autonomic nervous signal circuits which suppress the progression of the disease by activating the gastric ghrelin expression, the neural signal transduction in the brain, and the release of IGF-1 from the liver.