The LepRdb/db mice model for studying glycation in the context of diabetes.

Axel GuilbaudMichael HowsamCéline Niquet-LéridonFlorian DelgusteEric BoulangerFrederic J Tessier

Published in: Diabetes/metabolism research and reviews (2019)

The db/db model better reflected the characteristics of human T2D compared with the DIO models and exhibited greater formation and accumulation of both furosine and protein-bound CML in all of the organs tested here.

Keyphrases

endothelial cells
type diabetes
small molecule
pluripotent stem cells
insulin resistance