Indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase expression in HPV infection, SILs, and cervical cancer.
Paloma Almeida VenancioMarcia Edilaine Lopes ConsolaroSophie Françoise DerchainEnrique BoccardoLuisa Lina VillaSilvya Stuchi Maria-EnglerAna CampaMichelle Garcia DiscacciatiPublished in: Cancer cytopathology (2019)
The upregulation of IDO expression in leukocytes and squamous cells in HPV-associated SIL and SCC suggests that immunosuppressive mechanisms involving tryptophan metabolism may have a role in cervical carcinogenesis. Although previous studies have suggested the role of IDO in HPV pathogenesis, this is the first evidence of TDO involvement in the process. Furthermore, the current data emphasize the role of leukocytes, especially neutrophil-like cells, as an IDO source.