Amplified Type I Interferon Response in Sjögren's Disease via Ectopic Toll-Like Receptor 7 Expression in Salivary Gland Epithelial Cells Induced by Lysosome-Associated Membrane Protein 3.
Hiroyuki NakamuraTsutomu TanakaChangyu ZhengSandra A AfioneTatsuya AtsumiMasayuki NoguchiFabiola Reis OliveiraAna Carolina F MottaFernando ChahudEduardo Melani RochaBlake M WarnerJohn A ChioriniPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2024)
Epithelial LAMP3 misexpression can be induced through enhanced type I IFN response in salivary glands. In addition, LAMP3 can promote type I IFN production via ectopic TLR-7 expression in salivary gland epithelial cells. This positive feedback loop can contribute to maintaining LAMP3 misexpression and amplifying type I IFN production in salivary glands, which plays an essential role in the pathophysiology of SjD.
Keyphrases
- toll like receptor
- immune response
- dendritic cells
- loop mediated isothermal amplification
- poor prognosis
- nuclear factor
- inflammatory response
- binding protein
- high glucose
- long non coding rna
- diabetic rats
- transcription factor
- living cells
- systemic lupus erythematosus
- disease activity
- rheumatoid arthritis
- fluorescent probe