The functionality of African-specific variants in the TGFB1 regulatory region and their potential role in HIVAN.

M NelJ-M BuysF C J BothaN WearneS PrinceJeannine M Heckmann

Published in: Clinical and experimental nephrology (2017)

African-specific haplotypes lower TGFB1-promoter activity and expression levels and HIV-Tat upregulates TGFB1 promoter activity irrespective of the haplotype.

Keyphrases

transcription factor
dna methylation
gene expression
antiretroviral therapy
poor prognosis
hiv infected
hiv positive
human immunodeficiency virus
hiv testing
copy number
hiv aids
binding protein
south africa
long non coding rna