TOPK promotes the development of psoriasis and worenine alleviates psoriasiform dermatitis by inhibiting TOPK activity.

Hui Lu Yingze Huang Xiaofang Ni Tengfei Ma Teding Chang Man Liu Nijie Li Peijiang Lu Ping Yuan Lin Liu Fei Shi Juanjuan Xiao Han Xiao Qiuhong Duan Feng Zhu

Published in: Journal of the European Academy of Dermatology and Venereology : JEADV (2023)

T-lymphokine-activated killer cell-originated protein kinase promotes the development of psoriasis. Therefore, TOPK might be a promising drug target for the prevention and treatment of psoriasis. Worenine alleviates psoriasiform dermatitis by inhibiting TOPK activity, providing new strategies for clinical intervention.

Keyphrases

atopic dermatitis
signaling pathway
protein kinase
randomized controlled trial
mouse model
single cell
cell therapy
stem cells
emergency department
combination therapy
electronic health record
replacement therapy