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Control of meiotic double-strand-break formation by ATM: local and global views.

Agnieszka LukaszewiczJulian LangeScott KeeneyMaria Jasin
Published in: Cell cycle (Georgetown, Tex.) (2018)
DNA double-strand breaks (DSBs) generated by the SPO11 protein initiate meiotic recombination, an essential process for successful chromosome segregation during gametogenesis. The activity of SPO11 is controlled by multiple factors and regulatory mechanisms, such that the number of DSBs is limited and DSBs form at distinct positions in the genome and at the right time. Loss of this control can affect genome integrity or cause meiotic arrest by mechanisms that are not fully understood. Here we focus on the DSB-responsive kinase ATM and its functions in regulating meiotic DSB numbers and distribution. We review the recently discovered roles of ATM in this context, discuss their evolutionary conservation, and examine future research perspectives.
Keyphrases
  • dna damage
  • dna repair
  • dna damage response
  • genome wide
  • single molecule
  • copy number
  • cell cycle
  • protein protein
  • dna methylation
  • protein kinase
  • amino acid