Progesterone Receptor-Mediated Regulation of Cellular Glucose and 18 F-Fluorodeoxyglucose Uptake in Breast Cancer.

Thus, progesterone and progestins increase FDG uptake in T47D breast cancer cells through the classical action of PR as a ligand-activated transcription factor. Ligand-activated PR ultimately increases expression and activity of proteins involved in glucose uptake, glycolysis, and the pentose phosphate pathway.