Critical appraisal and issues regarding generalisability of comparative effectiveness studies of NOACs in atrial fibrillation and their relation to clinical trial data: a systematic review.
Eveline M BungeBen van HoutSylvia HaasGeorgios SpentzourisAlexander CohenPublished in: BMJ open (2021)
Comparisons regarding effectiveness and safety between NOACs on the basis of observational data, even after correction for baseline characteristics, may not be reliable due to unmeasured confounders, channelling bias and insufficient sample size. These limitations should be kept in mind when results of these studies are used to decide on ranking NOAC treatment options.
Keyphrases
- oral anticoagulants
- atrial fibrillation
- clinical trial
- electronic health record
- big data
- case control
- left atrial
- heart failure
- left atrial appendage
- direct oral anticoagulants
- machine learning
- percutaneous coronary intervention
- randomized controlled trial
- artificial intelligence
- phase ii
- deep learning
- coronary artery disease