Respiratory microbiome disruption and risk for ventilator-associated lower respiratory tract infection.
James J HarriganHatem AbdallahErik L ClarkeArman OganisianJason A RoyEbbing LautenbachEmily ReeseyMagda WernovskyPam TolomeoZygmunt MorawskiJerry JacobMichael A GrippiBrendan J KellyPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)
Cross-sectional MDIs have limited ability to discriminate VA-LRTI risk during prolonged mechanical ventilation, but persistent lower respiratory tract microbiome disruption, best characterized by consecutive days with low Shannon diversity, may identify a population at high risk for infection and may help target infection prevention interventions.