Determination of antidepressants in human urine extracted by magnetic multiwalled carbon nanotube poly(styrene-co-divinylbenzene) composites and separation by capillary electrophoresis.
Khaled MurtadaFernando de AndrésAngel RíosMohammed ZougaghPublished in: Electrophoresis (2018)
Poly(styrene-co-divinylbenzene)-coated magnetic multiwalled carbon nanotube composite synthesized by in-situ high temperature combination and precipitation polymerization of styrene-co-divinylbenzene has been employed as a magnetic sorbent for the solid phase extraction of antidepressants in human urine samples. Fluoxetine, venlafaxine, citalopram and sertraline were, afterwards, separated and determined by capillary electrophoresis with diode array detection. The presence of magnetic multiwalled carbon nanotubes in native poly(styrene-co-divinylbenzene) not only simplified sample treatment but also enhanced the adsorption efficiencies, obtaining extraction recoveries higher than 89.5% for all analytes. Moreover, this composite can be re-used at least ten times without loss of efficiency and limits of detection ranging from 0.014 to 0.041 μg/mL were calculated. Additionally, precision values ranging from 0.08 to 7.50% and from 0.21 to 3.05% were obtained for the responses and for the migration times of the analytes, respectively.
Keyphrases
- carbon nanotubes
- molecularly imprinted
- solid phase extraction
- capillary electrophoresis
- mass spectrometry
- liquid chromatography
- high performance liquid chromatography
- liquid chromatography tandem mass spectrometry
- endothelial cells
- tandem mass spectrometry
- simultaneous determination
- high temperature
- gas chromatography mass spectrometry
- major depressive disorder
- induced pluripotent stem cells
- gas chromatography
- ultra high performance liquid chromatography
- high resolution
- high resolution mass spectrometry
- pluripotent stem cells
- real time pcr
- label free
- sensitive detection
- quantum dots