Discovery of Novel Pyrimidine Based Small Molecule Inhibitors as VEGFR-2 Inhibitors: Design, Synthesis, and Anti-Cancer Studies.
Sachin A DhawaleSantosh N MokalePratap S DabhadePublished in: Current computer-aided drug design (2024)
The results demonstrate that at the cellular and enzyme levels, the synthetic compounds SP2 are similarly effective as cabozantinib. The cell cycle and apoptosis data demonstrate the effectiveness of the suggested compounds. Based on the findings of docking studies, cytotoxic effects, in vitro VEGFR-2 inhibition, apoptosis, and cell cycle arrest, this research has given us identical or more effective VEGFR-2 inhibitors.
Keyphrases
- cell cycle arrest
- cell cycle
- small molecule
- cell death
- pi k akt
- protein protein
- cell proliferation
- vascular endothelial growth factor
- oxidative stress
- endoplasmic reticulum stress
- randomized controlled trial
- case control
- molecular dynamics
- signaling pathway
- high throughput
- big data
- endothelial cells
- machine learning
- deep learning