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Transplanted human photoreceptors transfer cytoplasmic material but not to the recipient mouse retina.

Margaret T HoKotoe KawaiDhana AbdoLacrimioara ComanitaArturo Ortin-MartinezYui UenoEmily TsaoAzam Rastgar-MoghadamChang XueHong CuiValerie A WallaceMolly S Shoichet
Published in: Stem cell research & therapy (2024)
While xenograft models are not a tractable system to study material transfer of human photoreceptors, these findings demonstrate that human retinal organoid-derived photoreceptors are competent donors for material transfer and thus may be useful to treat retinal degenerative disease.
Keyphrases
  • endothelial cells
  • diabetic retinopathy
  • induced pluripotent stem cells
  • optical coherence tomography
  • pluripotent stem cells
  • electron transfer