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Biological controls for standardization and interpretation of adaptive immune receptor repertoire profiling.

Johannes TrückAnne EugsterPierre BarennesChristopher M TiptonEline T Luning PrakDavide BagnaraCinque SotoJacob S SherkowAimee S PayneMarie-Paule LefrancAndrew Farmernull nullMagnolia BostickEncarnita Mariotti-Ferrandiz
Published in: eLife (2021)
Use of adaptive immune receptor repertoire sequencing (AIRR-seq) has become widespread, providing new insights into the immune system with potential broad clinical and diagnostic applications. However, like many high-throughput technologies, it comes with several problems, and the AIRR Community was established to understand and help solve them. We, the AIRR Community's Biological Resources Working Group, have surveyed scientists about the need for standards and controls in generating and annotating AIRR-seq data. Here, we review the current status of AIRR-seq, provide the results of our survey, and based on them, offer recommendations for developing AIRR-seq standards and controls, including future work.
Keyphrases
  • single cell
  • rna seq
  • high throughput
  • current status
  • mental health
  • genome wide
  • healthcare
  • dna methylation
  • cross sectional
  • machine learning
  • binding protein
  • climate change