Promotion of Calcium/Calmodulin-Dependent Protein Kinase 4 by GLUT1-Dependent Glycolysis in Systemic Lupus Erythematosus.
Tomohiro KogaTomohito SatoKaori FurukawaShimpei MorimotoYushiro EndoMasataka UmedaRemi SumiyoshiShoichi FukuiShin-Ya KawashiriNaoki IwamotoKunihiro IchinoseMami TamaiTomoki OriguchiHideki NakamuraAtsushi KawakamiPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2019)
The results of the study indicate that the activity of CaMK4 could be responsible for glycolysis, which contributes to the production of IL-17, and CaMK4 may contribute to aberrant expression of GLUT1 in T cells from patients with active SLE.