Ex vivo transdermal delivery of 3 H-labelled atovaquone solid drug nanoparticles: a comparison of topical, intradermal injection and microneedle assisted administration.

Sam MorrisMark LongAlison Savage Andrew Owen Steven P Rannard Helen Cauldbeck

Published in: Nanoscale advances (2023)

Inherent barrier properties of the skin impose significant challenges to the transdermal delivery of drugs to systemic circulation. Here, the ex vivo transdermal permeation and deposition of an anti-malarial prophylactic atovaquone solid drug nanoformulation is radiometrically evaluated following application of a solid microneedle format.

Keyphrases

drug induced
wound healing
adverse drug
emergency department