Effectiveness and feasibility of cardiovascular disease personalized prevention on high polygenic risk score subjects: a randomized controlled pilot study.
Margus ViigimaaMikk JürissonHeti PisarevRuth KaldaHelene AlavereAlar IrsAet SaarKrista FisherKristi LällKrista Kruuv-KäoNina J MarsElisabeth WidenSamuli RipattiAndres MetspaluPublished in: European heart journal open (2022)
Most of our outcome measures were in favour of this intervention. Participants achieved larger changes in cholesterol and blood pressure values. The vast majority (98.4%) of family physicians are interested in continuing to use genetic risk assessment in practice.
Keyphrases
- primary care
- risk assessment
- randomized controlled trial
- cardiovascular disease
- blood pressure
- healthcare
- human health
- systematic review
- genome wide
- hypertensive patients
- heavy metals
- low density lipoprotein
- heart rate
- medical education
- type diabetes
- quality improvement
- copy number
- cardiovascular risk factors
- coronary artery disease
- gene expression
- blood glucose
- insulin resistance
- climate change
- skeletal muscle
- weight loss
- glycemic control