Prognostic indicators and outcomes of hospitalised COVID-19 patients with neurological disease: An individual patient data meta-analysis.
Bhagteshwar SinghSuzannah LantSofia CividiniJonathan W S CattrallLynsey C GoodwinLaura BenjaminBenedict D MichaelAyaz KhawajaAline de Moura Brasil MatosWalid A AlkeridyAndrea PilottoDurjoy LahiriRebecca RawlinsonSithembinkosi MhlangaEvelyn C LopezBrendan F SargentAnushri SomasundaranArina TamborskaGlynn WebbKomal YounasYaqub Al SamiHeavenna BabuTristan BanksFrancesco CavallieriMatthew CohenEmma DaviesShalley DharAnna Fajardo ModolHamzah FarooqJeffrey HarteSamuel HeyAlbert JosephDileep KarthikappallilDaniel KassahunGareth LipungaRachel MasonThomas MintonGabrielle MondJoseph PoxonSophie RabasGermander SoothillMarialuisa ZeddeKonstantin YenkoyanBruce BrewErika ContiniLucette CysiqueXin ZhangPietro MaggiVincent van PeschJérome LechienSven SaussezAlex HeyseMaria Lúcia Brito FerreiraCristiane N SoaresIsabel ElicerLaura Eugenín-von BernhardiWaleng Ñancupil ReyesRong YinMohammed A AzabFoad Abd-AllahAhmed ElkadySimon EscalardJean-Christophe CorvolCécile DelormePierre TattevinKévin BigautNorbert LorenzDaniel HornussJonas HospSiegbert RiegDirk WagnerBenjamin KnierPaul LingorAndrea Sylvia WinklerAthena Sharifi-RazaviShima T MoeinSeyedAhmad SeyedAlinaghiSaeidreza JamaliMoghadamSiahkaliMauro MorassiAlessandro PadovaniMarcello GiuntaIlenia LibriSimone BerettaSabrina RavagliaMatteo FoschiPaolo CalabresiGuido PrimianoSerenella ServideiNicola Biagio MercuriClaudio LiguoriMariangela PierantozziLoredana SarmatiFederica BosoSilvia GarazzinoSara MariottoKimani N PatrickOana CostacheAlexander PincherleFrederikus A KlokRoger MezaVerónica CabreiraSofia R ValdoleirosVanessa OliveiraIgor KaimovskyAlla GuekhtJasmine KohEva Fernández DíazJosé María Barrios-LópezCristina Guijarro-CastroÁlvaro Beltrán-CorbelliniJavier Martínez-PolesAlba María Diezma-MartínMaria Isabel Morales-CasadoSergio García GarcíaGautier BrevilleMatteo CoenMarjolaine UginetRaphaël Bernard-ValnetRenaud Du PasquierYildiz KayaLoay H AbdelnourClaire RiceHamish MorrisonSylviane DefresSaif HudaNoelle EnrightJane HassellLucio D'AnnaMatthew BengerLaszlo SztrihaEamon RaithKrishna ChinthapalliRoss NortleyRoss PatersonArvind ChandrathevaDavid J WerringSamir DervisevicKirsty HarknessAshwin PintoDinesh JillellaScott BeachKulothungan GunasekaranIvan Rocha Ferreira Da SilvaKrishna NalleballeJonathan SantoroTyler ScullenLora KahnCarla Y KimKiran T ThakurRajan JainThirugnanam UmapathiTimothy R NicholsonJames J SejvarEva Maria Hodelnull nullCatrin Tudur SmithTom SolomonPublished in: PloS one (2022)
Neurological COVID-19 disease poses a considerable burden in terms of disease outcomes and use of hospital resources from prolonged intensive care and inpatient admission; preliminary data suggest these may differ according to WHO regions and country income levels. The different risk factors for encephalopathy and stroke suggest different disease mechanisms which may be amenable to intervention, especially in those who develop neurological symptoms after hospital admission.
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