Evolutionary trade-off between heat shock resistance, growth at high temperature, and virulence expression in Salmonella Typhimurium.
Daniel BerdejoJulien MortierAlexander CambréMalgorzata SobotaRonald Van EykenTom Dongmin KimKristof VanoirbeekDiego Garcia-GonzaloRafael PagánMédéric DiardAbram AertsenPublished in: mBio (2024)
Typhimurium mutants that are compromised in the activity of the DnaJ heat shock protein. While these mutants obtained massively increased heat resistance, their virulence became greatly attenuated. Our observations, therefore, reveal a delicate balance between optimal tuning of stress response and virulence features in bacterial pathogens.
Keyphrases
- heat shock protein
- heat shock
- escherichia coli
- antimicrobial resistance
- pseudomonas aeruginosa
- staphylococcus aureus
- biofilm formation
- high temperature
- heat stress
- listeria monocytogenes
- genome wide
- poor prognosis
- cystic fibrosis
- oxidative stress
- dna methylation
- gene expression
- wild type
- long non coding rna
- multidrug resistant