Long noncoding RNA CCDC144NL-AS1 knockdown induces naïve-like state conversion of human pluripotent stem cells.
Yingying WangBaosen GuoZengrong XiaoHaijun LinXi ZhangYueqiang SongYalei LiXuehu GaoJinjun YuZhihua ShaoXuekun LiYuping LuoSiguang LiPublished in: Stem cell research & therapy (2019)
Our study unveils an unexpected role of a lncRNA, CCDC144NL-AS1, in the naïve-like state conversion of human PSCs, providing a new perspective to further understand the regulation process of human early pluripotency states conversion. It is suggested that CCDC144NL-AS1 can be potentially valuable for future research on deriving higher quality naïve state human PSCs and promoting their therapeutic applications.