Spilanthes filicaulis (Schumach. & Thonn.) C. D Adam leaf extract prevents assault of streptozotocin on liver cells via inhibition of oxidative stress and activation of the NrF2/Keap1, PPARγ, and PTP1B signaling pathways.
Oluwafemi Adeleke OjoFiyinfoluwa Stephen OladepoAkingbolabo Daniel OgunlakinDamilare IyinKristi AyokunleAdeshina Isaiah OdugbemiDare Ezekiel BabatundeAdebola Busola OjoOmolola Adenike Ajayi-OdokoBasiru Olaitan AjiboyeSamuel Olatunde DahunsiPublished in: PloS one (2024)
It can be concluded from the data presented in this study that MESFL exerts a protective effect on diabetic rats due to its antidiabetic, antioxidant, antihyperlipidemic and antiapoptotic effects and may be considered a treatment for T2DM.
Keyphrases
- diabetic rats
- oxidative stress
- induced apoptosis
- dna damage
- ischemia reperfusion injury
- signaling pathway
- cell cycle arrest
- epithelial mesenchymal transition
- mouse model
- pi k akt
- metabolic syndrome
- fatty acid
- cell proliferation
- small molecule
- adipose tissue
- weight loss
- glycemic control
- artificial intelligence
- heat stress