JKAMP inhibits the osteogenic capacity of adipose-derived stem cells in diabetic osteoporosis by modulating the Wnt signaling pathway through intragenic DNA methylation.

Shuanglin PengSirong ShiGang TaoYanjing LiDexuan XiaoLang WangQing HeXiaoxiao CaiJingang Xiao

Published in: Stem cell research & therapy (2021)

Intragenic DNA methylation inhibits the osteogenic ability of DOP-ASCs by suppressing expression of JKAMP and the Wnt signaling pathway. This study shows an epigenetic explanation for the reduced osteogenic ability of DOP-ASCs and provides a potential therapeutic target to prevent and treat osteoporosis.

Keyphrases

dna methylation
signaling pathway
mesenchymal stem cells
bone marrow
pi k akt
genome wide
postmenopausal women
gene expression
cell proliferation
stem cells
bone mineral density
epithelial mesenchymal transition
poor prognosis
wound healing
type diabetes
copy number
long non coding rna
body composition