Activated wake systems in narcolepsy type 1.

Ling ShanSuzan LinssenZoe HartemanFleur den DekkerLamis ShukerRawien BalesarNicole BreesuwsmaJasper AninkJingru ZhouGert Jan LammersDick F SwaabRolf Fronczek

Published in: Annals of neurology (2023)

Our findings suggest an upregulation of activity by histamine neurons and remaining CRH neurons in NT1. This may explain earlier reports of normal basal plasma cortisol levels but lower levels after dexamethasone suppression. Alternatively, CRH neurons co-expressing AVP neurons are less vulnerable. This article is protected by copyright. All rights reserved.

Keyphrases

spinal cord
low dose
poor prognosis
cell proliferation
high dose
signaling pathway
adverse drug
electronic health record