How do lifestyle factors modify the association between genetic predisposition and obesity-related phenotypes? A 4-way decomposition analysis using UK Biobank.

Mengrong ZhangJoey WardRona J StrawbridgeCarlos Celis-MoralesJill P PellDonald M LyallFrederick Ka Wing Ho

Published in: BMC medicine (2024)

A substantial proportion of the association between genetic predisposition to obesity/central obesity and phenotypic obesity/central obesity was explained by lifestyles. Future studies with repeated measures of obesity and lifestyle would be needed to clarify causation.

Keyphrases

metabolic syndrome
weight loss
insulin resistance
high fat diet induced
type diabetes
weight gain
cardiovascular disease
adipose tissue
physical activity
body mass index
cross sectional