Long Non-Coding RNA and Acute Leukemia.
Gabriela Marisol Cruz-MirandaAlfredo Hidalgo-MirandaDiego Alberto Bárcenas-LópezJuan Carlos Nuñez-EnriquezJulián Ramírez BelloJuan Manuel Mejía-AranguréSilvia Jiménez-MoralesPublished in: International journal of molecular sciences (2019)
Acute leukemia (AL) is the main type of cancer in children worldwide. Mortality by this disease is high in developing countries and its etiology remains unanswered. Evidences showing the role of the long non-coding RNAs (lncRNAs) in the pathophysiology of hematological malignancies have increased drastically in the last decade. In addition to the contribution of these lncRNAs in leukemogenesis, recent studies have suggested that lncRNAs could be used as biomarkers in the diagnosis, prognosis, and therapeutic response in leukemia patients. The focus of this review is to describe the functional classification, biogenesis, and the role of lncRNAs in leukemogenesis, to summarize the evidence about the lncRNAs which are playing a role in AL, and how these genes could be useful as potential therapeutic targets.
Keyphrases
- long non coding rna
- genome wide identification
- poor prognosis
- genome wide analysis
- network analysis
- newly diagnosed
- end stage renal disease
- ejection fraction
- young adults
- transcription factor
- papillary thyroid
- bone marrow
- prognostic factors
- gene expression
- type diabetes
- risk factors
- dna methylation
- human health
- case control