Mixing short- and long-acting local anaesthetics in peripheral nerve blocks: Protocol for a systematic review and meta-analysis.

Jens L TembergSanja PisljagicMathias T SteensbaekSina YousefLana ChafranskaKai H W LangeChristian RotheAnders Kehlet NørskovMathias MaagaardLars H Lundstrøm

Published in: Acta anaesthesiologica Scandinavica (2023)

We will conduct a meta-analysis of the extracted data, and the risk of bias for each study will be evaluated. We will perform a Trial Sequential Analysis, subgroup, and sensitivity analyses and assess the overall risk of publication bias. Finally, we will evaluate the review using the GRADE principles.

Keyphrases

peripheral nerve
phase iii
randomized controlled trial
study protocol
electronic health record
big data
artificial intelligence
double blind