'Pain-free TRUS B': a phase 3 double-blind placebo-controlled randomized trial of methoxyflurane with periprostatic local anaesthesia to reduce the discomfort of transrectal ultrasonography-guided prostate biopsy (ANZUP 1501).
Dickon HayneJeremy GrummetDavid EspinozaSteve P McCombieVenu ChalasaniKate S FordMark FrydenbergPeter J GillingBarbara GordonCynthia HawksAlex KonstantatosAndrew J MartinAnthony NixonColin O'BrienManish I PatelShomik SenguptaShekib ShahbazShalini SubramaniamScott WilliamsHenry H WooMartin R StocklerIan D DavisNick Buchannull nullPublished in: BJU international (2021)
We found no evidence that methoxyflurane improved pain scores at 15 min, however, improvements were seen in patient-reported discomfort, overall experience, and willingness to undergo repeat biopsies.
Keyphrases
- placebo controlled
- double blind
- patient reported
- chronic pain
- pain management
- prostate cancer
- neuropathic pain
- clinical trial
- study protocol
- ultrasound guided
- magnetic resonance imaging
- phase ii
- phase ii study
- phase iii
- spinal cord injury
- postoperative pain
- randomized controlled trial
- magnetic resonance
- spinal cord
- benign prostatic hyperplasia