MiRNAs that target amyloid precursor protein processing machinery in extracellular vesicles and particles derived from oral squamous cells carcinoma.

Fernando GalvãoMichele Patricia RodePaloma Santos de CamposGisele Eva BruchVirgínia Mendes CarregalAndré Ricardo MassensiniBibiana Franzen Matte Marcelo Lazzaron LamersTânia Beatriz Creczynski-PasaIonara Rodrigues Siqueira

Published in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2023)

Our results indicate changes in miRNAs that target APP machinery processing in EVPs derived from OSCC cell lines of different aggressiveness, which may be involved with abnormal miRNA expression in OSCC tissue and/or releasing tumor suppressor miRNA.

Keyphrases

induced apoptosis
poor prognosis
cell cycle arrest
binding protein
high grade
low grade
signaling pathway
cell death
protein protein
amino acid
small molecule
cell proliferation