Evaluating IL-21 as a Potential Therapeutic Target in Crohn's Disease.

Thomas Lindebo HolmDitte TornehaveHenrik SøndergaardPeter Helding KvistBodil-Cecilie SondergaardLene HansenMette Brunsgaard HermitKristine HolgersenSandra VergoKlaus Stensgaard FrederiksenClaus HaaseDorthe Lundsgaard

Published in: Gastroenterology research and practice (2018)

Our study shows that patients with CD have significant expression of IL-21 and IL-21R in the gut. As well, we show that neutralization of IL-21 in experimental T cell-driven colitis is associated with a reduction in clinical and pathological findings. This amelioration seems to be associated with a reduction in colon-infiltrating neutrophils.

Keyphrases

poor prognosis
climate change
binding protein
long non coding rna
ulcerative colitis