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P. aeruginosa tRNA-fMet halves secreted in outer membrane vesicles suppress lung inflammation in Cystic Fibrosis.

Zhongyou LiRoxanna BarnabyAmanda NymonCarolyn RocheKatja KoeppenAlix AshareDeborah A HoganScott A GerberDouglas J TaatjesThomas H HamptonBruce A Stanton
Published in: bioRxiv : the preprint server for biology (2024)
. 5' tRNA-fMet halves are delivered into host cells after OMVs fuse with lipid rafts in CF-HBEC and down-regulate protein expression of MAPK10, IKBKG, and EP300, which suppresses IL-8 secretion and neutrophils in the lungs. A reduction in neutrophils in CF BALF is predicted to improve lung function and decrease lung damage.
Keyphrases
  • cystic fibrosis
  • lung function
  • oxidative stress
  • induced apoptosis
  • signaling pathway
  • pseudomonas aeruginosa
  • cell cycle arrest
  • pi k akt
  • air pollution
  • fatty acid
  • endoplasmic reticulum stress